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Intravitreal bevacizumab (Avastin) treatment of choroidal neovascularisation in patients with angioid streaks.
- Source :
-
The British journal of ophthalmology [Br J Ophthalmol] 2009 Jan; Vol. 93 (1), pp. 47-51. Date of Electronic Publication: 2008 Oct 29. - Publication Year :
- 2009
-
Abstract
- Objective: To evaluate the safety and efficacy of intravitreal bevacizumab (Avastin) as treatment for choroidal neovascularisation (CNV) associated with angioid streaks<br />Methods: A non-randomised, interventional case series conducted on eyes with subfoveal CNV associated with angioid streaks. Intravitreal bevacizumab (1.25 mg in 0.05 ml) was injected into nine eyes of six patients between August 2005 and December 2007. Treatment efficacy was assessed based on pre- and post-treatment visual acuity and optical coherence tomography (OCT).<br />Results: With a mean follow-up of 19 months (range 10 to 28 months), the best corrected visual acuity improved by three or more lines in four eyes (44.4%), remained within two lines of baseline in four eyes (44.4%) and decreased by three or more lines in one eye (11.1%). Central foveal thickness (CFT) measured by OCT decreased an average of 67.7 microm (range +11 to -175 microm) with an average improvement in standardised change in macular thickening of 46.6% (range -12% to +84.5%). No injection-related complications or drug-related side effects were observed.<br />Conclusions: Intravitreal bevacizumab for the treatment of subfoveal CNV secondary to angioid streaks mildly reduced central foveal thickness with a trend toward stabilisation of visual acuity. Additional follow-up and a larger patient cohort are needed to evaluate the long-term effects of this treatment.
- Subjects :
- Aged
Aged, 80 and over
Angiogenesis Inhibitors adverse effects
Antibodies, Monoclonal adverse effects
Antibodies, Monoclonal, Humanized
Bevacizumab
Choroidal Neovascularization complications
Choroidal Neovascularization physiopathology
Female
Fluorescein Angiography
Fovea Centralis physiology
Humans
Male
Middle Aged
Retrospective Studies
Tomography, Optical Coherence
Treatment Outcome
Visual Acuity drug effects
Angiogenesis Inhibitors administration & dosage
Angioid Streaks complications
Antibodies, Monoclonal administration & dosage
Choroidal Neovascularization drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2079
- Volume :
- 93
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The British journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 18971238
- Full Text :
- https://doi.org/10.1136/bjo.2008.143461