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Estimating the extent of vaccine-derived poliovirus infection.
- Source :
-
PloS one [PLoS One] 2008; Vol. 3 (10), pp. e3433. Date of Electronic Publication: 2008 Oct 29. - Publication Year :
- 2008
-
Abstract
- Background: Eight outbreaks of paralytic polio attributable to circulating vaccine-derived poliovirus (cVDPV) have highlighted the risks associated with oral poliovirus vaccine (OPV) use in areas of low vaccination coverage and poor hygiene. As the Polio Eradication Initiative enters its final stages, it is important to consider the extent to which these viruses spread under different conditions, so that appropriate strategies can be devised to prevent or respond to future cVDPV outbreaks.<br />Methods and Findings: This paper examines epidemiological (temporal, geographic, age, vaccine history, social group, ascertainment), and virological (type, genetic diversity, virulence) parameters in order to infer the numbers of individuals likely to have been infected in each of these cVDPV outbreaks, and in association with single acute flaccid paralysis (AFP) cases attributable to VDPVs. Although only 114 virologically-confirmed paralytic cases were identified in the eight cVDPV outbreaks, it is likely that a minimum of hundreds of thousands, and more likely several million individuals were infected during these events, and that many thousands more have been infected by VDPV lineages within outbreaks which have escaped detection.<br />Conclusions: Our estimates of the extent of cVDPV circulation suggest widespread transmission in some countries, as might be expected from endemic wild poliovirus transmission in these same settings. These methods for inferring extent of infection will be useful in the context of identifying future surveillance needs, planning for OPV cessation and preparing outbreak response plans.
- Subjects :
- Adolescent
Age Distribution
Child
Child, Preschool
Disease Outbreaks statistics & numerical data
Dominican Republic epidemiology
Egypt epidemiology
Genetic Variation physiology
Haiti epidemiology
Humans
Indonesia epidemiology
Infant
Poliomyelitis immunology
Poliomyelitis virology
Poliovirus genetics
Poliovirus isolation & purification
Poliovirus Vaccines genetics
Poliovirus Vaccines immunology
Population Surveillance
Social Class
Poliomyelitis epidemiology
Poliomyelitis etiology
Poliovirus Vaccines adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 3
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 18958288
- Full Text :
- https://doi.org/10.1371/journal.pone.0003433