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Memory-enhancing treatments reverse the impairment of inhibitory avoidance retention in sepsis-surviving rats.
- Source :
-
Critical care (London, England) [Crit Care] 2008; Vol. 12 (5), pp. R133. Date of Electronic Publication: 2008 Oct 28. - Publication Year :
- 2008
-
Abstract
- Introduction: Survivors from sepsis have presented with long-term cognitive impairment, including alterations in memory, attention, concentration, and global loss of cognitive function. Thus, we evaluated the effects of memory enhancers in sepsis-surviving rats.<br />Methods: The rats underwent cecal ligation and perforation (CLP) (sepsis group) with 'basic support' (saline at 50 mL/kg immediately and 12 hours after CLP plus ceftriaxone at 30 mg/kg and clindamycin at 25 mg/kg 6, 12, and 18 hours after CLP) or sham-operated (control group). After 10 or 30 days, rats were submitted to an inhibitory avoidance task. After task training, animals received injections of saline, epinephrine, naloxone, dexamethasone, or glucose. Twenty-four hours afterwards, animals were submitted to the inhibitory avoidance test.<br />Results: We demonstrated that memory enhancers reversed impairment in the sepsis group 10 and 30 days after sepsis induction. This effect was of lower magnitude when compared with sham animals 10 days, but not 30 days, after sepsis.<br />Conclusions: Using different pharmacologic approaches, we conclude that the adrenergic memory formation pathways are responsive in sepsis-surviving animals.
- Subjects :
- Animals
Avoidance Learning physiology
Cognition Disorders etiology
Cognition Disorders physiopathology
Male
Memory physiology
Nootropic Agents pharmacology
Rats
Rats, Wistar
Receptors, Adrenergic physiology
Retention, Psychology drug effects
Retention, Psychology physiology
Sepsis complications
Sepsis physiopathology
Survival Analysis
Avoidance Learning drug effects
Cognition Disorders drug therapy
Memory drug effects
Nootropic Agents therapeutic use
Sepsis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1466-609X
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Critical care (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 18957125
- Full Text :
- https://doi.org/10.1186/cc7103