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Impact of the novel hepatotropic viruslike agent NV-F during chronic hepatitis C virus infection.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2008 Dec 15; Vol. 198 (12), pp. 1742-8. - Publication Year :
- 2008
-
Abstract
- NV-F is a novel hepatotropic viruslike agent. To investigate the impact of the NV-F agent during chronic hepatitis C virus (HCV) infection, 101 consecutive patients with chronic HCV infection were evaluated. NV-F DNA in serum samples and NV-F antigen expression in liver tissues were assessed. All patients subsequently received a 6-month course of interferon-based antiviral therapy. Of the 101 patients, 30 (29.7%) were positive for serum NV-F DNA. Immunohistochemical analysis revealed positive NV-F antigen expression in the liver in 14 of these 30 patients. Patients positive for serum NV-F DNA had significantly higher serum aminotransferase levels (P < .001) and higher Knodell histology activity index values (P < .001). The sustained virological response rate for HCV clearance was not significantly different between patients with and those without detectable serum NV-F DNA. In conclusion, coinfection of the NV-F agent in chronic HCV infection is associated with more severe hepatitis activity.
- Subjects :
- Adult
Antibodies, Viral blood
Antigens, Viral isolation & purification
Antiviral Agents therapeutic use
DNA, Viral genetics
DNA, Viral isolation & purification
Female
Genotype
Hepacivirus genetics
Hepatitis C, Chronic blood
Hepatitis C, Chronic drug therapy
Humans
Immunohistochemistry
Interferon alpha-2
Interferon-alpha therapeutic use
Liver pathology
Liver virology
Male
Middle Aged
Polyethylene Glycols therapeutic use
Recombinant Proteins
Ribavirin therapeutic use
Hepatitis C, Chronic complications
Hepatitis Viruses genetics
Hepatitis Viruses isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 198
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 18954259
- Full Text :
- https://doi.org/10.1086/593178