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Nesiritide in acute decompensated heart failure: current status and future perspectives.
- Source :
-
Reviews in cardiovascular medicine [Rev Cardiovasc Med] 2008 Summer; Vol. 9 (3), pp. 151-8. - Publication Year :
- 2008
-
Abstract
- Acute decompensated heart failure (ADHF) is a growing public health problem with high mortality and costs. ADHF often, if not usually, occurs in the setting of cardiovascular and noncardiovascular comorbidities as well as advanced age. New insights provide support for the concept of heart failure as a state of deficiency of and/or resistance to endogenous B-type natriuretic peptide. The primary goals of ADHF therapy are to relieve symptoms and optimize volume status with minimal side effects. Few therapies are proven to effectively do so. Nesiritide is a balanced vasodilator with favorable neurohumoral effects and is superior to placebo in providing rapid symptom relief and to nitroglycerin in reducing filling pressures. Recent trials confirm a lack of renal toxicity at recommended doses. An adequately powered multinational mortality trial is underway. Nesiritide represents a proven therapy for normotensive/hypertensive ADHF patients with severe symptoms at rest.
- Subjects :
- Acute Disease
Antihypertensive Agents therapeutic use
Clinical Trials as Topic
Cost-Benefit Analysis
Drug Costs
Heart Failure metabolism
Heart Failure mortality
Heart Failure physiopathology
Humans
Hypertension drug therapy
Kidney drug effects
Kidney physiopathology
Natriuretic Peptide, Brain adverse effects
Natriuretic Peptide, Brain economics
Natriuretic Peptide, Brain metabolism
Patient Selection
Risk Assessment
Treatment Outcome
Vasodilator Agents adverse effects
Vasodilator Agents economics
Heart Failure drug therapy
Natriuretic Peptide, Brain therapeutic use
Vasodilator Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6550
- Volume :
- 9
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Reviews in cardiovascular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 18953274