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Deterioration in asthma control when subjects receiving fluticasone propionate/salmeterol 100/50 mcg Diskus are "stepped-down".
- Source :
-
The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2008 Oct; Vol. 45 (8), pp. 681-7. - Publication Year :
- 2008
-
Abstract
- In this study, 647 subjects stable on fluticasone propionate/salmeterol Diskus 100/50 mcg BID (FSC) were randomized to continue FSC 100/50 mcg BID or "step down" to either fluticasone propionate (FP) 100 mcg BID, salmeterol (SAL) 50 mcg BID, or montelukast (MON) 10 mg once daily for 16 weeks. Overall asthma control significantly improved in the FSC group; whereas, "stepping down" to FP, SAL, or MON resulted in deterioration in asthma control, as determined by decreased measures of lung function and clinical features. This study provides support that treatment of both inflammation and smooth muscle dysfunction may be necessary to achieve and maintain asthma control in patients uncontrolled on ICS.
- Subjects :
- Albuterol administration & dosage
Asthma physiopathology
Cyclopropanes
Dose-Response Relationship, Drug
Double-Blind Method
Drug Combinations
Female
Fluticasone
Fluticasone-Salmeterol Drug Combination
Forced Expiratory Flow Rates drug effects
Humans
Kaplan-Meier Estimate
Male
Patient Satisfaction
Peak Expiratory Flow Rate drug effects
Salmeterol Xinafoate
Sulfides
Surveys and Questionnaires
Acetates administration & dosage
Albuterol analogs & derivatives
Androstadienes administration & dosage
Anti-Asthmatic Agents administration & dosage
Asthma drug therapy
Quinolines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1532-4303
- Volume :
- 45
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of asthma : official journal of the Association for the Care of Asthma
- Publication Type :
- Academic Journal
- Accession number :
- 18951261
- Full Text :
- https://doi.org/10.1080/02770900802168695