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Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS -SLE (depression).
- Source :
-
Journal of autoimmunity [J Autoimmun] 2008 Dec; Vol. 31 (4), pp. 393-8. Date of Electronic Publication: 2008 Oct 22. - Publication Year :
- 2008
-
Abstract
- Unlabelled: Systemic lupus erythematosus (SLE) is an autoimmune disease associated with more than 100 different autoantibodies, some of which may be associated with specific neuropsychiatric (NPSLE) manifestations. Injection of anti-P ribosomal antibodies (anti-P) directly to the brain ventricles of mice induces depression manifested by increased immobility time in the forced swim test (FST).<br />Methods: Mice were injected intracerebroventricularily (ICV) with affinity-purified human anti-P antibodies or normal commercial IgG as control. Mice were examined for depression by the forced swimming test (FST) and for olfactory function by the smell threshold test. Treatments included the antidepressant drug fluoxetine or aroma therapy by exposure to lemon or cinnamon odor.<br />Results: Mice injected with anti-P developed depression-like behavior, which improved significantly upon treatment with fluoxetine. Depressed mice had a significant deficit in olfactory function which was not reversed by fluoxetine. Exposure of anti-P-injected mice to lemon odor was associated with some improvement of the immobility time, a measure of depression.<br />Conclusions: ICV injection of anti-P induces both depression-like behavior and impaired olfactory function in mice. Fluoxetine and possibly lemon odor exposure improve depressive behavior in these mice.
- Subjects :
- Animals
Antidepressive Agents, Second-Generation pharmacology
Cerebral Ventricles drug effects
Cerebral Ventricles immunology
Depression etiology
Disease Models, Animal
Female
Fluoxetine pharmacology
Humans
Lupus Erythematosus, Systemic complications
Mice
Mice, Inbred C3H
Odorants
Olfaction Disorders etiology
Olfactory Perception immunology
Autoantibodies immunology
Depression immunology
Lupus Erythematosus, Systemic immunology
Olfaction Disorders immunology
Ribosomal Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0896-8411
- Volume :
- 31
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of autoimmunity
- Publication Type :
- Academic Journal
- Accession number :
- 18947972
- Full Text :
- https://doi.org/10.1016/j.jaut.2008.09.002