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E-I balance and human diseases - from molecules to networking.
- Source :
-
Frontiers in molecular neuroscience [Front Mol Neurosci] 2008 Mar 28; Vol. 1, pp. 2. Date of Electronic Publication: 2008 Mar 28 (Print Publication: 2008). - Publication Year :
- 2008
-
Abstract
- Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I) balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation.
Details
- Language :
- English
- ISSN :
- 1662-5099
- Volume :
- 1
- Database :
- MEDLINE
- Journal :
- Frontiers in molecular neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 18946535
- Full Text :
- https://doi.org/10.3389/neuro.02.002.2008