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A clinical study of Japanese cedar (Cryptomeria japonica) pollen-induced asthma.

Authors :
Maeda Y
Akiyama K
Shida T
Source :
Allergology international : official journal of the Japanese Society of Allergology [Allergol Int] 2008 Dec; Vol. 57 (4), pp. 413-7. Date of Electronic Publication: 2008 Nov 01.
Publication Year :
2008

Abstract

Background: Grass and birch pollens are known to induce asthma. However there are few reports about other pollen-induced asthma. Japanese cedar is the most common allergen in rhinitis in Japan but is controversial on whether it can provoke asthma.<br />Methods: To clarify Japanese cedar pollen-induced asthma, we studied adult patients who were sensitized only to the Japanese cedar (CAP-RAST > = 2) and had symptoms of asthma during the cedar season. We defined cedar asthma as a patient who satisfied the 2 criteria mentioned above.<br />Results: We found 6 adult asthma patients who fulfilled the two criteria. Five patients suffered from cedar pollinosis in addition to asthma, and 1 patient had no pollinosis. The cedar pollinosis preceded asthma in 3 cases and occurred at almost the same time in the other 2 cases. Pulmonary function was normal in these cases (FEV 1%, mean +/- SD, 76.5 +/- 10%), with a high threshold value in the non-specific airway hypersensitivity test (Ach-PC20, 2,696 to 20,000 microg/ml, 9294 +/- 2) and low total IgE (101 +/- 86 IU/ml). In the allergen provocation test, 3 subjects showed both an immediate and late asthmatic reaction.<br />Conclusions: We concluded that Japanese cedar pollen could provoke not only pollinosis but also asthma in adults.

Details

Language :
English
ISSN :
1323-8930
Volume :
57
Issue :
4
Database :
MEDLINE
Journal :
Allergology international : official journal of the Japanese Society of Allergology
Publication Type :
Academic Journal
Accession number :
18946237
Full Text :
https://doi.org/10.2332/allergolint.O-08-543