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A clinical study of Japanese cedar (Cryptomeria japonica) pollen-induced asthma.
- Source :
-
Allergology international : official journal of the Japanese Society of Allergology [Allergol Int] 2008 Dec; Vol. 57 (4), pp. 413-7. Date of Electronic Publication: 2008 Nov 01. - Publication Year :
- 2008
-
Abstract
- Background: Grass and birch pollens are known to induce asthma. However there are few reports about other pollen-induced asthma. Japanese cedar is the most common allergen in rhinitis in Japan but is controversial on whether it can provoke asthma.<br />Methods: To clarify Japanese cedar pollen-induced asthma, we studied adult patients who were sensitized only to the Japanese cedar (CAP-RAST > = 2) and had symptoms of asthma during the cedar season. We defined cedar asthma as a patient who satisfied the 2 criteria mentioned above.<br />Results: We found 6 adult asthma patients who fulfilled the two criteria. Five patients suffered from cedar pollinosis in addition to asthma, and 1 patient had no pollinosis. The cedar pollinosis preceded asthma in 3 cases and occurred at almost the same time in the other 2 cases. Pulmonary function was normal in these cases (FEV 1%, mean +/- SD, 76.5 +/- 10%), with a high threshold value in the non-specific airway hypersensitivity test (Ach-PC20, 2,696 to 20,000 microg/ml, 9294 +/- 2) and low total IgE (101 +/- 86 IU/ml). In the allergen provocation test, 3 subjects showed both an immediate and late asthmatic reaction.<br />Conclusions: We concluded that Japanese cedar pollen could provoke not only pollinosis but also asthma in adults.
- Subjects :
- Adult
Antigens, Plant immunology
Asthma complications
Asthma physiopathology
Bronchial Provocation Tests
Cryptomeria immunology
Female
Humans
Injections, Intradermal
Male
Middle Aged
Plant Extracts immunology
Pollen immunology
Respiratory Sounds drug effects
Respiratory Sounds immunology
Rhinitis, Allergic, Seasonal complications
Rhinitis, Allergic, Seasonal physiopathology
Seasons
Skin Tests
Sneezing drug effects
Sneezing immunology
Antigens, Plant administration & dosage
Asthma immunology
Plant Extracts administration & dosage
Rhinitis, Allergic, Seasonal immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1323-8930
- Volume :
- 57
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Allergology international : official journal of the Japanese Society of Allergology
- Publication Type :
- Academic Journal
- Accession number :
- 18946237
- Full Text :
- https://doi.org/10.2332/allergolint.O-08-543