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Synthesis and anticonvulsant activity of some quinazolin-4-(3H)-one derivatives.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2008; Vol. 13 (10), pp. 2557-69. - Publication Year :
- 2008
-
Abstract
- A number of 3-substituted-2-(substituted-phenoxymethyl) quinazolin-4(3H)-one derivatives 4a,b, 5a-c, 6, 7a-f, 8a-e and 9a,b have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H-NMR, MS). A preliminary evaluation of the anticonvulsant activity of the prepared compounds has indicated that compounds 4b, 7b-f, 8a and 9b exhibit significant anticonvulsant activity, while compounds 6, 8b and 8d show mild to moderate activity.
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 13
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 18927518
- Full Text :
- https://doi.org/10.3390/molecules13102557