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Performance of a sterile meniscal allograft in an ovine model.
- Source :
-
Clinical orthopaedics and related research [Clin Orthop Relat Res] 2009 Jul; Vol. 467 (7), pp. 1868-76. Date of Electronic Publication: 2008 Oct 16. - Publication Year :
- 2009
-
Abstract
- Meniscus transplantation is indicated for persistent pain in a meniscectomized knee. Currently, grafts are prepared aseptically, which provides limited protection against donor-derived infection. The performance of a novel, sterilized meniscus was compared with an aseptically prepared one in an experimental model. Twenty-two sheep were divided into three groups: aseptic meniscal allograft, sterile meniscal allograft, and medial meniscectomy. Animals were euthanized 2 and 4 months after surgery. Meniscal assessments included cell viability, histology, and biomechanical testing. Articular cartilage was evaluated through histology and Outerbridge scoring. Aseptic and sterile allografts had cell viabilities of 59.7% and 58.7%, respectively, at 4 months, which was less than native controls. Grafts had decreased compressive strength at 4 months compared with their preimplantation moduli and were weaker than native menisci. In operated knees, the tibial plateau had more severe degenerative changes, although Outerbridge scores were similar between operated groups. Overall, the allografts were similar in their cellularity and biomechanical properties but were inferior to the native tissue at these end points. The severity of chondral damage in the allograft knees could not be distinguished from meniscectomized joints. The sterilization process does not appear to compromise tissue integrity and provides additional allograft safety.
- Subjects :
- Animals
Biopsy
Cell Survival
Compressive Strength physiology
Menisci, Tibial pathology
Models, Animal
Sheep
Tibia pathology
Tibia physiology
Transplantation, Homologous
Asepsis
Graft Survival physiology
Menisci, Tibial physiology
Menisci, Tibial transplantation
Surgical Wound Infection prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1528-1132
- Volume :
- 467
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Clinical orthopaedics and related research
- Publication Type :
- Academic Journal
- Accession number :
- 18923880
- Full Text :
- https://doi.org/10.1007/s11999-008-0567-y