Oral squamous cell carcinoma: a mono-institutional epidemiological study on 462 cases highlighting differences among young and adult patients.

Aim: Despite several diagnostic and therapeutic advances, an increasing incidence of oral squamous cell carcinoma (OSCC) especially among young individuals has been observed in different parts of the world. Aim of this study was to delineate the profile of patients with OSCC in particular among young people.
Methods: Between 1977-2004, the medical records of 462 patients (mean age: 64.18 years, male-to-female ratio 2.1:1) with a diagnosis of OSCC were retrieved and successively analysed, with details of demographic data, staging, histological grading, treatment modality and risk factor profile. Overall, 43 (9.3%) patients were less of 45 years old, and among these, the male-to-female ratio was 2.9:1 with the median age of 38 years. Most patients had stage II (37.5%) or III (29.2) disease, only 9.7% of the patients had stage IV. The most common histological gradings were well or moderately differentiated (98,5%). The most common involved site was the tongue (40.1%). A large number of patients (45.4%) received treatment with either surgery alone or a combination of surgery and other adjuvant therapy (45.9%).
Results: Collectively, these data indicate that OSCC remains a constant worldwide health problem. In addition, the occurrence of OSCC in young people is relatively high. Traditional risk habits including smoking and alcohol consumption remain the most important factors in the development of OSCC.
Conclusion: Therefore, our data suggested that the OSCC prevention with early detection, early treatment intervention, and withdrawal from risk habits must be devised and advised also for patients in southern Italy.