Neuromyelitis optica and multiple sclerosis in sisters.

Authors :: Cabrera-Gómez JA
Ramón-Pérez L
Saiz A
Llerena-Fernández P
Fernández-Fernández L
Ercilla G
Grass-Fernández D
Robinson-Agramonte MA
Romero-García K
Macías-Betancourt R
Galvizu-Sánchez R
Otero-Motolá C
Sojo-Gómez M
Aguilar-Arias C
Rodríguez-Cordero M
González-Quevedo A
Source :: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2009 Feb; Vol. 15 (2), pp. 269-71. Date of Electronic Publication: 2008 Oct 15.
Publication Year :: 2009
Abstract: Introduction: The association of neuromyelitis optica (NMO) and multiple sclerosis (MS) has been reported, but details of the cases were not described. We report two Venezuelan Caucasian sisters with human leukocyte antigen (HLA) typing.<br />Results: Patient 1 fulfilled McDonald, et al. criteria with HLA A*24; B*07,*15; DRB1*01,*16 (DR2 positive). Patient 2 fulfilled the NMO revised criteria of Wingerchuck, et al. with HLA A*02,*24; B*07,*40; DRB1*04,*08, similar to Canadian aboriginal NMO cases and the Yukpa population from Venezuela.<br />Conclusion: These cases confirmed the coexistence of NMO and MS in sisters, and further studies are needed to understand the genetic linkage between these diseases.