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Maedi-visna: the meningoencephalitis in naturally occurring cases.
- Source :
-
Journal of comparative pathology [J Comp Pathol] 2009 Jan; Vol. 140 (1), pp. 1-11. Date of Electronic Publication: 2008 Oct 14. - Publication Year :
- 2009
-
Abstract
- Lesions were examined at different levels of the central nervous system (CNS) in 64 sheep with natural maedi-visna (MV) meningoencephalitis. All animals showed lesions in more than one of the CNS locations examined; the lesions in the cranial regions were periventricular, while those in the spinal cord affected the white matter funicles. Lesions were found particularly in the cerebellar peduncles (non-suppurative meningoencephalitis), followed by the corpus callosum, hippocampus and thoracic spinal cord. Vascular, infiltrative and malacic histopathological patterns were recognized. One pattern predominated in each section examined, although mixed forms occurred. Vascular lesions occurred with similar frequency at all CNS levels, but infiltrative and malacic lesions predominated at rostral and caudal levels, respectively. Cells consistent with macrophages and shown immunohistochemically to be associated with MV virus were seen in malacic and infiltrative lesions, at the periphery of damaged areas.
- Subjects :
- Animals
Antigens, Viral
Corpus Callosum immunology
Corpus Callosum pathology
Corpus Callosum virology
Hippocampus immunology
Hippocampus pathology
Hippocampus virology
Macrophages pathology
Meningoencephalitis pathology
Meningoencephalitis virology
Sheep
Sheep Diseases immunology
Spinal Cord immunology
Spinal Cord pathology
Spinal Cord virology
Tegmentum Mesencephali immunology
Tegmentum Mesencephali pathology
Tegmentum Mesencephali virology
Visna immunology
Visna virology
Meningoencephalitis veterinary
Sheep Diseases pathology
Sheep Diseases virology
Visna pathology
Visna-maedi virus
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9975
- Volume :
- 140
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of comparative pathology
- Publication Type :
- Academic Journal
- Accession number :
- 18922546
- Full Text :
- https://doi.org/10.1016/j.jcpa.2008.07.010