Back to Search
Start Over
Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study.
- Source :
-
BMC medical genetics [BMC Med Genet] 2008 Oct 14; Vol. 9, pp. 90. Date of Electronic Publication: 2008 Oct 14. - Publication Year :
- 2008
-
Abstract
- Background: Body fat mass distribution and deposition are determined by multiple environmental and genetic factors. Obesity is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes. We previously identified evidence for genotype-by-diabetes interaction on obesity traits in Strong Heart Family Study (SHFS) participants. To localize these genetic effects, we conducted genome-wide linkage scans of obesity traits in individuals with and without type 2 diabetes, and in the combined sample while modeling interaction with diabetes using maximum likelihood methods (SOLAR 2.1.4).<br />Methods: SHFS recruited American Indians from Arizona, North and South Dakota, and Oklahoma. Anthropometric measures and diabetes status were obtained during a clinic visit. Marker allele frequencies were derived using maximum likelihood methods estimated from all individuals and multipoint identity by descent sharing was estimated using Loki. We used variance component linkage analysis to localize quantitative trait loci (QTLs) influencing obesity traits. We tested for evidence of additive and QTL-specific genotype-by-diabetes interactions using the regions identified in the diabetes-stratified analyses.<br />Results: Among 245 diabetic and 704 non-diabetic American Indian individuals, we detected significant additive gene-by-diabetes interaction for weight and BMI (P < 0.02). In analysis accounting for QTL-specific interaction (P < 0.001), we detected a QTL for weight on chromosome 1 at 242 cM (LOD = 3.7). This chromosome region harbors the adiponectin receptor 1 gene, which has been previously associated with obesity.<br />Conclusion: These results suggest distinct genetic effects on body mass in individuals with diabetes compared to those without diabetes, and a possible role for one or more genes on chromosome 1 in the pathogenesis of obesity.
- Subjects :
- Adult
Aged
Arizona
Body Mass Index
Case-Control Studies
Chromosomes, Human, Pair 1
Diabetes Mellitus, Type 2 complications
Female
Genome-Wide Association Study
Genotype
Humans
Lod Score
Male
Microsatellite Repeats
Middle Aged
North Dakota
Obesity complications
Oklahoma
Receptors, Adiponectin genetics
South Dakota
Diabetes Mellitus, Type 2 genetics
Indians, North American genetics
Obesity genetics
Quantitative Trait Loci
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2350
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- BMC medical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 18854016
- Full Text :
- https://doi.org/10.1186/1471-2350-9-90