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High molecular weight FGF2: the biology of a nuclear growth factor.
- Source :
-
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2009 Jan; Vol. 66 (2), pp. 225-35. - Publication Year :
- 2009
-
Abstract
- Fibroblast growth factor 2 (FGF2) is one of the most studied growth factors to date. Most attention has been dedicated to the smallest, 18 kDa FGF2 variant that is released by cells and acts through activation of cell-surface FGF-receptor tyrosine kinases. There are, however, several higher molecular weight (HMW) variants of FGF2 that rarely leave their producing cells, are retained in the nucleus and act independently of FGF-receptors (FGFR). Despite significant evidence documenting the expression and intracellular trafficking of HMW FGF2, many important questions remain about the physiological roles and mechanisms of action of HMW FGF2. In this review, we summarize the current knowledge about the biology of HMW FGF2, its role in disease and areas for future investigation.
- Subjects :
- Animals
Fibroblast Growth Factor 2 genetics
Fibroblast Growth Factor 2 metabolism
Gene Expression Regulation
Humans
Molecular Weight
Phenotype
Protein Isoforms genetics
Receptors, Fibroblast Growth Factor genetics
Ribonucleoprotein, U2 Small Nuclear metabolism
Ribosomal Proteins metabolism
SMN Complex Proteins metabolism
Protein Isoforms chemistry
Protein Isoforms metabolism
Receptors, Fibroblast Growth Factor chemistry
Receptors, Fibroblast Growth Factor metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1420-9071
- Volume :
- 66
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cellular and molecular life sciences : CMLS
- Publication Type :
- Academic Journal
- Accession number :
- 18850066
- Full Text :
- https://doi.org/10.1007/s00018-008-8440-4