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Malaria research in the post-genomic era.
- Source :
-
Nature [Nature] 2008 Oct 09; Vol. 455 (7214), pp. 751-6. - Publication Year :
- 2008
-
Abstract
- For many pathogens the availability of genome sequence, permitting genome-dependent methods of research, can partially substitute for powerful forward genetic methods (genome-independent) that have advanced model organism research for decades. In 2002 the genome sequence of Plasmodium falciparum, the parasite causing the most severe type of human malaria, was completed, eliminating many of the barriers to performing state-of-the-art molecular biological research on malaria parasites. Although new, licensed therapies may not yet have resulted from genome-dependent experiments, they have produced a wealth of new observations about the basic biology of malaria parasites, and it is likely that these will eventually lead to new therapeutic approaches. This review will focus on the basic research discoveries that have depended, in part, on the availability of the Plasmodium genome sequences.
- Subjects :
- Animals
Drug Design
Genetic Variation genetics
Genetic Variation immunology
Humans
Malaria drug therapy
Malaria epidemiology
Malaria prevention & control
Plasmodium immunology
Plasmodium pathogenicity
Genome, Protozoan genetics
Genomics
Malaria parasitology
Plasmodium genetics
Plasmodium physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 455
- Issue :
- 7214
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 18843360
- Full Text :
- https://doi.org/10.1038/nature07361