Back to Search
Start Over
[Effects of pingyu capsule on signal transduction of rats with chronic stress-induced depression].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2008 Jul; Vol. 33 (14), pp. 1743-6. - Publication Year :
- 2008
-
Abstract
- Objective: To observe the effects of Pingyu capsule on such important regulatory factors as cAMP, PKA and PKC of the signal transduction in rats with chronic stress-induced depression.<br />Method: Wistar male rats were randomly divided into control group, model group, paroxetine group, and Pingyu capsule low, middle and high doses groups; rats in all groups but the control group were fed in single cage for 21 days and were given such irritations as lightening stroke on pelma, ice water swimming, pyretic fumigation and tail clipping during this period; lobe cortex and hippocampus of all rats were taken out for detection of the cAMP content by means of radioactive immunization, PKA and PKC content by Elisa, and the PKA and PKC activity by radioactive isotope.<br />Result: Content of cAMP in lobe cortex and hippocampus, content and activity of PKA in hippocampus, and content of PKC in lobe cortex of rats in the model group were lower than those in the normal group. Pingyu capsule and paroxetine can increase them.<br />Conclusion: The anti-depression effect of Pingyu capsule maybe related to its function of adjusting the signal transduction of cAMP-PKA.
- Subjects :
- Animals
Capsules administration & dosage
Capsules pharmacology
Cyclic AMP metabolism
Cyclic AMP-Dependent Protein Kinases metabolism
Disease Models, Animal
Drugs, Chinese Herbal administration & dosage
Enzyme-Linked Immunosorbent Assay
Male
Protein Kinase C metabolism
Radioimmunoassay
Rats
Rats, Wistar
Depression metabolism
Drugs, Chinese Herbal pharmacology
Signal Transduction drug effects
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 33
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 18841783