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Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?
- Source :
-
FEBS letters [FEBS Lett] 2008 Oct 29; Vol. 582 (25-26), pp. 3614-8. Date of Electronic Publication: 2008 Oct 01. - Publication Year :
- 2008
-
Abstract
- Recently, using an animal model of Charcot-Marie-Tooth human disorder, we showed that ascorbic acid (AA) represses PMP22 gene expression by acting on intracellular cAMP concentrations. In this work, we present kinetics data on the inhibitory effect of AA upon adenylate cyclase activity. The data show that this molecule acts as a competitive inhibitor of the enzyme, a finding that opens new pharmacological avenues.
- Subjects :
- Adenylyl Cyclases genetics
Animals
Ascorbic Acid physiology
Cell Line
Cyclic AMP biosynthesis
Gene Expression drug effects
Isoenzymes antagonists & inhibitors
Isoenzymes genetics
Kinetics
Mice
Adenylyl Cyclase Inhibitors
Ascorbic Acid pharmacology
Cyclic AMP antagonists & inhibitors
Enzyme Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 582
- Issue :
- 25-26
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 18835269
- Full Text :
- https://doi.org/10.1016/j.febslet.2008.09.040