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Characteristic behavioral anomalies in rats prenatally exposed to 5-bromo-2'-deoxyuridine.
- Source :
-
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2009 Feb; Vol. 27 (1), pp. 81-6. Date of Electronic Publication: 2008 Sep 11. - Publication Year :
- 2009
-
Abstract
- The aim of the present study was to characterize behavioral anomalies in rats prenatally exposed to 5-bromo-2'-deoxyuridine, a useful model of hyperactive disorder. Rats were treated with BrdU at 50mg/kg IP or carboxymethylcellulose, its vehicle, on gestational Days 9 through 15, and their offsprings were subjected to behavioral tests. Rats prenatally exposed to 5-bromo-2'-deoxyuridine showed higher locomotor activity levels when the lights were turned off, and these levels kept increasing throughout the dark cycle. In an elevated plus maze, the rats prenatally exposed to 5-bromo-2'-deoxyuridine exhibited decreased anxiety-related behavior, including higher open arm entries and a longer time spent per one open arm entry when compared with rats prenatally exposed to carboxymethylcellulose. Methylphenidate, a psychostimulant that suppresses hyperactivity in humans with attention-deficit hyperactivity disorder, increased locomotor activity in both rats, with a greater sensitivity in rats prenatally exposed to 5-bromo-2'-deoxyuridine. Desipramine, a specific noradrenaline uptake inhibitor, normalized the hyperactivity of rats prenatally exposed to 5-bromo-2'-deoxyuridine. Paroxetine, a selective serotonin reuptake inhibitor, also normalized the hyperactivity and the low anxiety-related behavior in the elevated plus maze. These results suggest that rats prenatally exposed to 5-bromo-2'-deoxyuridine are hyperactive and exhibit a lower anxiety level. Dysfunctional monoaminergic neurons may be, at least in part, the cause of the behavioral anomalies.
- Subjects :
- Animals
Animals, Newborn
Antidepressive Agents, Tricyclic pharmacology
Antimetabolites toxicity
Anxiety Disorders chemically induced
Anxiety Disorders physiopathology
Behavior, Animal drug effects
Behavior, Animal physiology
Biogenic Monoamines metabolism
Brain physiopathology
Central Nervous System Stimulants pharmacology
Disease Models, Animal
Female
Male
Maze Learning drug effects
Mental Disorders congenital
Mental Disorders physiopathology
Motor Activity drug effects
Pregnancy
Prenatal Exposure Delayed Effects pathology
Prenatal Exposure Delayed Effects physiopathology
Rats
Rats, Sprague-Dawley
Selective Serotonin Reuptake Inhibitors pharmacology
Brain drug effects
Brain growth & development
Bromodeoxyuridine toxicity
Mental Disorders chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0736-5748
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 18834934
- Full Text :
- https://doi.org/10.1016/j.ijdevneu.2008.09.002