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Long-term pharmacologic neuroprotection after birth asphyxia: where do we stand?
Long-term pharmacologic neuroprotection after birth asphyxia: where do we stand?
- Source :
-
Neonatology [Neonatology] 2008; Vol. 94 (3), pp. 203-10. Date of Electronic Publication: 2008 Oct 02. - Publication Year :
- 2008
-
Abstract
- Perinatal hypoxia-ischemia or birth asphyxia is a serious complication with a high mortality and morbidity. For decades, neuroprotective options have been explored to reduce reperfusion and reoxygenation injury to the brain, which accounts for a substantial part of birth asphyxia-related brain damage. In this review, we focus on neuroprotective strategies with a long-term follow-up, reported in both experimental and clinical studies. Strategies related to modification of excitatory neurotransmitter production and action, reduction in free radical production and inflammation and neoneurogenesis will be briefly summarized. Since hypothermia has been proven to be beneficial for a selected group of asphyxiated neonates, we assume that a combination of this treatment option with a pharmacological means of neuroprotection will be the appropriate approach in the future. Finally, it is important to consider possible gender effects in view of the discussed pharmacological strategies.<br /> ((c) 2008 S. Karger AG, Basel.)
- Subjects :
- Animals
Animals, Newborn
Asphyxia Neonatorum drug therapy
Brain Diseases metabolism
Humans
Infant, Newborn
Reperfusion Injury metabolism
Reperfusion Injury prevention & control
Asphyxia Neonatorum metabolism
Brain blood supply
Brain Diseases prevention & control
Neuroprotective Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1661-7819
- Volume :
- 94
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neonatology
- Publication Type :
- Academic Journal
- Accession number :
- 18832856
- Full Text :
- https://doi.org/10.1159/000143723