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Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism.
- Source :
-
The Journal of biological chemistry [J Biol Chem] 2008 Nov 28; Vol. 283 (48), pp. 33276-86. Date of Electronic Publication: 2008 Oct 02. - Publication Year :
- 2008
-
Abstract
- The B chain of ricin was expressed and delivered to the endoplasmic reticulum of tobacco protoplasts where it disappeared with time in a manner consistent with degradation. This turnover did not occur in the vacuoles or upon secretion. Indeed, several lines of evidence indicate that, in contrast to the turnover of endoplasmic reticulum-targeted ricin A chain in the cytosol, the bulk of expressed ricin B chain was degraded in the secretory pathway.
- Subjects :
- Cytosol metabolism
Protoplasts cytology
Ricin pharmacology
Nicotiana cytology
Vacuoles metabolism
Valosin Containing Protein
Adenosine Triphosphatases metabolism
Cell Cycle Proteins metabolism
Endoplasmic Reticulum metabolism
Plant Proteins metabolism
Protoplasts metabolism
Ricin metabolism
Nicotiana metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9258
- Volume :
- 283
- Issue :
- 48
- Database :
- MEDLINE
- Journal :
- The Journal of biological chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18832379
- Full Text :
- https://doi.org/10.1074/jbc.M805222200