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Quantifying the impact of non-adherence to drug therapy: a technical note concerning an application of a branch and bound algorithm.
- Source :
-
Health care management science [Health Care Manag Sci] 2008 Sep; Vol. 11 (3), pp. 302-5. - Publication Year :
- 2008
-
Abstract
- Pharmacokinetic models typically rely on a key assumption that patients take their medication as prescribed, whereas this is often not the case. We present a branch and bound algorithm that can be used to estimate the time-varying probability that, given a specified pattern of nonadherence to a prescribed regimen, a patient receives no therapeutic benefit from treatment. Use of this algorithm is a much faster method for obtaining this probability than exhaustive computation of the relevant probability distribution. The use of this algorithm to assess, in quantitative terms, the impact of non-adherence on the effectiveness of treatment provides a rational basis for evaluating the potential harm to patients.
Details
- Language :
- English
- ISSN :
- 1386-9620
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Health care management science
- Publication Type :
- Academic Journal
- Accession number :
- 18826008
- Full Text :
- https://doi.org/10.1007/s10729-007-9047-2