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Chitosan-based thermosensitive hydrogel containing liposomes for sustained delivery of cytarabine.
- Source :
-
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2009 Jan; Vol. 35 (1), pp. 49-56. - Publication Year :
- 2009
-
Abstract
- Sustained release thermosensitive solution containing cytarabine-loaded liposome delivery system offers the possibility of reduced dosing frequency and sustained drug action. Biodegradable and biocompatible chitosan-beta-glycerophosphate (C-GP) thermosensitive solution having the property to gel at body temperature and to maintain its physical integrity for longer period of time was used. The C-GP solution containing cytarabine-loaded liposomes (CGPCLL) was studied, and the results showed that the cytarabine liposomes were capable of high encapsulation efficiency (85.2 +/- 2.58%) with the mean diameter of 220 +/- 6.9 nm of extruded cytarabine-loaded liposome. Furthermore, transmission electron microscopy showed spherical-shaped liposomes after extrusion with smooth surface. In vitro studies of CGPCLL in PBS buffer showed that this system can sustain release of encapsulated drug for more than 60 h compared with drug-loaded liposomal suspension (upto 48 h). Pharmacokinetic studies of CGPCLL resulted in higher t(1/2) (28.86 h) and AUC 2526.88 mug/mL h compared with cytarabine-loaded liposomal suspension (CLLS) and C-GP containing free cytarabine (CGPFC) in rats. CGPCLL was capable of sustaining the cytarabine release for more than 60 h in vivo compared with CLLS and CGPFC which showed maximum amount of drug release within 42 and 10 h, respectively. Thus, these results showed that the CGPCLL gels at body temperature and can sustain the delivery of cytarabine effectively.
- Subjects :
- Animals
Area Under Curve
Body Temperature
Cytarabine administration & dosage
Delayed-Action Preparations
Female
Half-Life
Hydrogels
Liposomes
Male
Microscopy, Electron, Transmission
Particle Size
Rats
Rats, Wistar
Time Factors
Chitosan chemistry
Cytarabine pharmacokinetics
Drug Carriers chemistry
Glycerophosphates chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5762
- Volume :
- 35
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Drug development and industrial pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 18821152
- Full Text :
- https://doi.org/10.1080/03639040802178144