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Pre-treatment effect of different doses of soy isoflavones on spatial learning and memory in an ovariectomized animal model of Alzheimer's disease.
- Source :
-
Pakistan journal of biological sciences : PJBS [Pak J Biol Sci] 2008 Apr 15; Vol. 11 (8), pp. 1114-9. - Publication Year :
- 2008
-
Abstract
- The aim of this study was to evaluate the effects of different doses of dietary soy meals (with or without isoflavone) on dementia in ovariectomized (OVX) animal model of Alzheimer's disease. Female Wistar's rats with the exception of intact group were ovariectomized at the first line of study. Animals were divided into 2 main groups: control (c) and pre-treatment groups. Animals in pre-treatment groups received one of five types of diet during four weeks prior Nucleus Basalis Magnocellularis (NBM) electrical lesion normal diet (0), 10 g soy with isoflavone (10), 20 g soy with isoflavone (20), 10 g soy without isoflavone (-10) and 20 g soy without isoflavone (-20) in 30 g daily diet. The spatial learning and memory were tested using Morris water maze after electrical lesion. Rats were trained in water maze to find a hidden escape Platform. Rats received 6 blocks that each block consisted of 3 trials. Following acquisition trials, one probe trial was conducted in which the platform was removed. Soy meal diet (with or without isoflavone) in ovariectomized rats with Alzheimer's disease caused improvement of performance across 18 trials of Acquisition. Our results suggest that soy meal is a potential alternative to estrogen in the prevention and treatment of Alzheimer's disease.
- Subjects :
- Animals
Body Weight drug effects
Dose-Response Relationship, Drug
Estrogens blood
Female
Isoflavones pharmacology
Rats
Rats, Wistar
Swimming
Time Factors
Alzheimer Disease drug therapy
Disease Models, Animal
Isoflavones administration & dosage
Isoflavones therapeutic use
Learning drug effects
Ovariectomy
Glycine max chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1028-8880
- Volume :
- 11
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Pakistan journal of biological sciences : PJBS
- Publication Type :
- Academic Journal
- Accession number :
- 18819549
- Full Text :
- https://doi.org/10.3923/pjbs.2008.1114.1119