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[Dysregulation of cooperative interactions of immunocytes and eosinophils in the mechanism of development of eosinophilia in Opisthorhis felineus invasion].
- Source :
-
Meditsinskaia parazitologiia i parazitarnye bolezni [Med Parazitol (Mosk)] 2008 Jul-Sep (3), pp. 13-7. - Publication Year :
- 2008
-
Abstract
- The authors studied the levels of mononuclear cell production of eosinophil-specific cytokines (IL-3, IL-5), the serum levels of eotaxin by enzyme immunoassay; the expression of the eosinophilic cell receptor apparatus by flow cytofluorometry in patients with acute and chronic Opisthorchis invasion. Eosinophilia-associated Opisthorchis invasion was found to be accompanied by a pronounced change in the serum production of the key cytokine regulators of eosinophilic homeostasis (elevated IL-3 and IL-5 levels) and eotaxin by peripheral blood mononuclear leukocytes. There was an increase in the number of receptor structures to eosinophil-specific cytokines (IL-5R-, IL-3R-, and CCR3-positive cells) in patients with opisthorchiasis. In vitro incubation of the eosinophils, obtained from patients with opisthorchiasis, with the recombinant forms of cytokines (IL-5, IL-3, and eotaxin) demonstrated the decreased expression of IL-5 and IL-3 receptors with the normal presentation of CCR3. With the developed acute helminthiasis, the revealed changes were more pronounced than those observed in chronic Opisthorchis invasion.
- Subjects :
- Adolescent
Adult
Animals
Cells, Cultured
Chemokines, CC blood
Chemokines, CC pharmacology
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Humans
Interleukin-3 biosynthesis
Interleukin-3 blood
Interleukin-3 pharmacology
Interleukin-5 biosynthesis
Interleukin-5 blood
Interleukin-5 pharmacology
Lymphocyte Count
Male
Middle Aged
Opisthorchiasis blood
Opisthorchiasis complications
Receptors, CCR3 immunology
Receptors, Interleukin-3 metabolism
Receptors, Interleukin-5 metabolism
Recombinant Proteins pharmacology
Eosinophilia immunology
Eosinophils immunology
Leukocytes, Mononuclear immunology
Opisthorchiasis immunology
Opisthorchis
Subjects
Details
- Language :
- Russian
- ISSN :
- 0025-8326
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Meditsinskaia parazitologiia i parazitarnye bolezni
- Publication Type :
- Academic Journal
- Accession number :
- 18819423