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Trans-stereoselectivity in the reaction between homophthalic anhydride and imines.
- Source :
-
Organic letters [Org Lett] 2008 Nov 06; Vol. 10 (21), pp. 4759-62. Date of Electronic Publication: 2008 Sep 25. - Publication Year :
- 2008
-
Abstract
- The reaction between homophthalic anhydride and imines in the presence of TiCl4 and diisopropyl ethyl amine is trans-selective. Under these conditions, the reaction using homochiral imines can be highly diastereoselective, thus allowing the synthesis of enantiopure 1,2,3,4-tetrahydro-1-oxoquinoline-4-carboxylic acids.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 10
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 18816130
- Full Text :
- https://doi.org/10.1021/ol801757r