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Endometrial stromal sarcoma: a population-based analysis.
- Source :
-
British journal of cancer [Br J Cancer] 2008 Oct 21; Vol. 99 (8), pp. 1210-5. Date of Electronic Publication: 2008 Sep 23. - Publication Year :
- 2008
-
Abstract
- To determine independent prognostic factors for the survival of patients with endometrial stromal sarcoma (ESS), data were abstracted from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute from 1988 to 2003. Kaplan-Meier and Cox proportional hazards models were used for analyses. Of 831 women diagnosed with ESS, the median age was 52 years (range: 17-96 years). In total, 59.9% had stage I, 5.1% stage II, 14.9% stage III, and 20.1% had stage IV disease. Overall, 13.0, 36.1, and 34.7% presented with grades 1, 2, and 3, respectively. Patients with stage I-II vs III-IV disease had 5 years DSS of 89.3% vs 50.3% (P<0.001) and those with grades 1, 2, and 3 cancers had survivals of 91.4, 95.4, and 42.1% (P<0.001). In multivariate analysis, older patients, black race, advanced stage, higher grade, lack of primary surgery, and nodal metastasis were independent prognostic factors for poorer survival. In younger women (<50 years) with stage I-II disease, ovarian-sparing procedures did not adversely impact survival (91.9 vs 96.2%; P=0.1). Age, race, primary surgery, stage, and grade are important prognostic factors for ESS. Excellent survival in patients with grade 1 and 2 disease of all stages supports the concept that these tumors are significantly different from grade 3 tumors. Ovarian-sparing surgeries may be considered in younger patients with early-stage disease.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Endometrial Neoplasms surgery
Female
Humans
Kaplan-Meier Estimate
Middle Aged
Prognosis
SEER Program
Sarcoma, Endometrial Stromal surgery
Endometrial Neoplasms mortality
Endometrial Neoplasms pathology
Sarcoma, Endometrial Stromal mortality
Sarcoma, Endometrial Stromal pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1827
- Volume :
- 99
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 18813312
- Full Text :
- https://doi.org/10.1038/sj.bjc.6604527