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Esophageal cancer associated with chronic mucocutaneous candidiasis. Could chronic candidiasis lead to esophageal cancer?
- Source :
-
Medical mycology [Med Mycol] 2009 Mar; Vol. 47 (2), pp. 201-5. Date of Electronic Publication: 2008 Sep 15. - Publication Year :
- 2009
-
Abstract
- Chronic mucocutaneous candidiasis (CMC) is a rare disease associated with immunodeficiency and characterized by persistent and refractory infections of the skin, appendages and mucous membranes caused by members of the genus Candida. Several different disorders are classified under this common denominator, including chronic and recurrent mucocutaneous infections due to Candida spp., which are sometimes linked to autoimmune endocrinopathies. These fungal infections are usually confined to the mucocutaneous surface, with little propensity for systemic disease or septicemia. We describe a patient with CMC who had an esophageal candidiasis refractory to treatment for decades and who developed an epidermoid esophageal cancer. No risk factors such as familiar susceptibility, smoking, alcohol drinking, or living in an endemic area were verified. This case report suggests the participation of nitrosamine compounds produced by chronic Candida infections as a risk factor for esophageal cancer in a patient with autosomal-dominant chronic mucocutaneous candidiasis.
- Subjects :
- Adult
Candida
Candidiasis, Chronic Mucocutaneous immunology
Candidiasis, Chronic Mucocutaneous microbiology
Humans
Immunologic Deficiency Syndromes complications
Immunologic Deficiency Syndromes immunology
Lymphocyte Activation immunology
Male
Candidiasis, Chronic Mucocutaneous complications
Carcinoma, Squamous Cell etiology
Esophageal Neoplasms etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1369-3786
- Volume :
- 47
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Medical mycology
- Publication Type :
- Academic Journal
- Accession number :
- 18798115
- Full Text :
- https://doi.org/10.1080/13693780802342545