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Effects of atorvastatin on vascular intimal hyperplasia: an experimental rodent model.
- Source :
-
Angiology [Angiology] 2009 Jun-Jul; Vol. 60 (3), pp. 370-7. Date of Electronic Publication: 2008 Sep 15. - Publication Year :
- 2009
-
Abstract
- Introduction: Vascular intimal hyperplasia is associated with increased mortality and morbidity. The authors investigated the effects of atorvastatin on vascular intimal hyperplasia.<br />Materials and Methods: Rats were divided into 4 groups. Groups 1, 2, and 3 had experimental aortic injury and received intraperitoneal injection of atorvastatin, solvent, or 0.9% NaCl, respectively. Group 4 was a nonintervention (laparotomy only) control group. Animals were sacrificed after 3 weeks. Blood samples and injured aortic segment were analyzed.<br />Results: Atorvastatin administration significantly lowered total and low-density lipoprotein cholesterol levels (P = .012 and P = .001, respectively), intima-media ratio (P = .002), and intimal smooth muscle cell accumulation (P < .05) in group 1. Luminal narrowing in animals in group 1 was significantly lower than that in animals in groups 2 and 3, but was higher than in animals in group 4 (P = .009).<br />Conclusions: Atorvastatin suppresses intimal hyerplasia and aids in intimal regeneration by lowering blood lipids and intimal smooth muscle cell accumulation.
- Subjects :
- Animals
Aorta, Abdominal drug effects
Aorta, Abdominal injuries
Aorta, Abdominal pathology
Atorvastatin
Cell Division drug effects
Cholesterol blood
Cholesterol, LDL blood
Male
Muscle, Smooth, Vascular drug effects
Muscle, Smooth, Vascular injuries
Muscle, Smooth, Vascular pathology
Rats
Rats, Wistar
Tunica Intima injuries
Tunica Intima pathology
Tunica Media injuries
Tunica Media pathology
Anticholesteremic Agents pharmacology
Fibromuscular Dysplasia pathology
Heptanoic Acids pharmacology
Pyrroles pharmacology
Tunica Intima drug effects
Tunica Media drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1940-1574
- Volume :
- 60
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 18796450
- Full Text :
- https://doi.org/10.1177/0003319708321102