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Effects of atorvastatin on vascular intimal hyperplasia: an experimental rodent model.

Authors :
Aydin U
Ugurlucan M
Gungor F
Ziyade S
Inan B
Banach M
Kalko Y
Yasar T
Source :
Angiology [Angiology] 2009 Jun-Jul; Vol. 60 (3), pp. 370-7. Date of Electronic Publication: 2008 Sep 15.
Publication Year :
2009

Abstract

Introduction: Vascular intimal hyperplasia is associated with increased mortality and morbidity. The authors investigated the effects of atorvastatin on vascular intimal hyperplasia.<br />Materials and Methods: Rats were divided into 4 groups. Groups 1, 2, and 3 had experimental aortic injury and received intraperitoneal injection of atorvastatin, solvent, or 0.9% NaCl, respectively. Group 4 was a nonintervention (laparotomy only) control group. Animals were sacrificed after 3 weeks. Blood samples and injured aortic segment were analyzed.<br />Results: Atorvastatin administration significantly lowered total and low-density lipoprotein cholesterol levels (P = .012 and P = .001, respectively), intima-media ratio (P = .002), and intimal smooth muscle cell accumulation (P < .05) in group 1. Luminal narrowing in animals in group 1 was significantly lower than that in animals in groups 2 and 3, but was higher than in animals in group 4 (P = .009).<br />Conclusions: Atorvastatin suppresses intimal hyerplasia and aids in intimal regeneration by lowering blood lipids and intimal smooth muscle cell accumulation.

Details

Language :
English
ISSN :
1940-1574
Volume :
60
Issue :
3
Database :
MEDLINE
Journal :
Angiology
Publication Type :
Academic Journal
Accession number :
18796450
Full Text :
https://doi.org/10.1177/0003319708321102