Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

Authors :: Barton A
Thomson W
Ke X
Eyre S
Hinks A
Bowes J
Plant D
Gibbons LJ
Wilson AG
Bax DE
Morgan AW
Emery P
Steer S
Hocking L
Reid DM
Wordsworth P
Harrison P
Worthington J
Source :: Nature genetics [Nat Genet] 2008 Oct; Vol. 40 (10), pp. 1156-9. Date of Electronic Publication: 2008 Sep 14.
Publication Year :: 2008
Abstract: The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.