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The tight junction protein CAR regulates cardiac conduction and cell-cell communication.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2008 Sep 29; Vol. 205 (10), pp. 2369-79. Date of Electronic Publication: 2008 Sep 15. - Publication Year :
- 2008
-
Abstract
- The Coxsackievirus-adenovirus receptor (CAR) is known for its role in virus uptake and as a protein of the tight junction. It is predominantly expressed in the developing brain and heart and reinduced upon cardiac remodeling in heart disease. So far, the physiological functions of CAR in the adult heart are largely unknown. We have generated a heart-specific inducible CAR knockout (KO) and found impaired electrical conduction between atrium and ventricle that increased with progressive loss of CAR. The underlying mechanism relates to the cross talk of tight and gap junctions with altered expression and localization of connexins that affect communication between CAR KO cardiomyocytes. Our results indicate that CAR is not only relevant for virus uptake and cardiac remodeling but also has a previously unknown function in the propagation of excitation from the atrium to the ventricle that could explain the association of arrhythmia and Coxsackievirus infection of the heart.
- Subjects :
- Animals
Atrioventricular Node physiology
Cadherins genetics
Cadherins metabolism
Cells, Cultured
Connexin 43 genetics
Connexin 43 metabolism
Coxsackie and Adenovirus Receptor-Like Membrane Protein
Coxsackievirus Infections metabolism
Coxsackievirus Infections physiopathology
Electrocardiography
Electrophysiology
Gap Junctions metabolism
Heart anatomy & histology
Heart embryology
Heart growth & development
Heart physiology
Heart Conduction System anatomy & histology
Humans
Mice
Mice, Knockout
Myocytes, Cardiac cytology
Myocytes, Cardiac metabolism
Phenotype
Receptors, Virus genetics
Cell Communication physiology
Heart Conduction System physiology
Receptors, Virus metabolism
Tight Junctions metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 205
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 18794341
- Full Text :
- https://doi.org/10.1084/jem.20080897