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An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.
- Source :
-
Biochemical Society transactions [Biochem Soc Trans] 2008 Oct; Vol. 36 (Pt 5), pp. 909-15. - Publication Year :
- 2008
-
Abstract
- The UPR (unfolded protein response) or ER (endoplasmic reticulum) stress response was first described 20 years ago. The field of ER stress has expanded tremendously since, moving from basic biology in yeast to human neurodegenerative, inflammatory, cardiovascular and neoplastic diseases. The ER stress response has also been implicated in diabetes development, affecting both insulin production by pancreatic beta-cells and insulin sensitivity in peripheral tissues. In the present mini-review, we focus on recent progress in the field of ER stress in pancreatic beta-cells. Recent advances in the understanding of lipotoxic ER stress and beta-cell recovery from ER stress are discussed.
- Subjects :
- Apoptosis physiology
Diabetes Mellitus physiopathology
Fatty Acids, Nonesterified metabolism
Humans
Insulin-Secreting Cells ultrastructure
Protein Biosynthesis
Signal Transduction physiology
Endoplasmic Reticulum metabolism
Insulin-Secreting Cells metabolism
Lipid Metabolism
Oxidative Stress
Subjects
Details
- Language :
- English
- ISSN :
- 0300-5127
- Volume :
- 36
- Issue :
- Pt 5
- Database :
- MEDLINE
- Journal :
- Biochemical Society transactions
- Publication Type :
- Academic Journal
- Accession number :
- 18793160
- Full Text :
- https://doi.org/10.1042/BST0360909