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Gamma-lactones alpha,beta- and beta,gamma-fused to carbocycles as novel antiproliferative drugs.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Oct 01; Vol. 18 (19), pp. 5171-3. Date of Electronic Publication: 2008 Aug 29. - Publication Year :
- 2008
-
Abstract
- A set of gamma-lactones alpha,beta-fused and beta,gamma-fused to carbocycles have been synthesized and evaluated for their in vitro antiproliferative activities using the human cancer cell lines SW1573 (lung), T-47D (breast) and WiDr (colon). The compounds are obtained by intramolecular ring closing metathesis of the corresponding dienes. Active compounds exhibited GI(50) values in the range 8-18 microM. A structure-activity relationship is also discussed.
- Subjects :
- Antineoplastic Agents chemical synthesis
Cell Line, Tumor
Cell Proliferation drug effects
Combinatorial Chemistry Techniques
Drug Design
Drug Screening Assays, Antitumor
Female
Humans
Lactones chemical synthesis
Molecular Structure
Stereoisomerism
Structure-Activity Relationship
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Lactones chemistry
Lactones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 18
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 18789684
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.08.098