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[Clinical significance of prostatic intraepithelial neoplasm and atypical small acinar proliferation: relationship with prostate cancer].
- Source :
-
Actas urologicas espanolas [Actas Urol Esp] 2008 Jul-Aug; Vol. 32 (7), pp. 680-5. - Publication Year :
- 2008
-
Abstract
- Introduction: Prostatic intraepithelial neoplasia (PIN) and atypical small acinar proliferation (ASAP) in the setting of prostatic needle biopsies are considered premalignant although questions still remain.<br />Objectives: In this paper, we have studied the clinical relevance of these histologic findings.<br />Material and Methods: We collected 138 subjects (108 PIN, 30 ASAP); in 67% we performed a second biopsy and the rate of cancer in this late biopsy were 19% and 27% respectively. We cannot identify any clinical factor to predict the finding of cancer in the re-biopsy (PSA, age, digital rectal examination, prostatic volume).<br />Results: In the follow-up, we observed higher rates of cancer for the ASAP; the finding of ASAP was the single clinical or histopathological factor that was an independent predictor of cancer.<br />Conclusions: We observed that the finding of ASAP was an indication for re-biopsy because of the higher rates of cancer; on the contrary, the paper of PIN in the prostatic needle biopsy still requires further investigation.
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0210-4806
- Volume :
- 32
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Actas urologicas espanolas
- Publication Type :
- Academic Journal
- Accession number :
- 18788482
- Full Text :
- https://doi.org/10.1016/s0210-4806(08)73914-7