Back to Search
Start Over
Predictors for clinical outcomes after accelerated partial breast intensity-modulated radiotherapy.
- Source :
-
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2009 May 01; Vol. 74 (1), pp. 92-7. Date of Electronic Publication: 2008 Sep 09. - Publication Year :
- 2009
-
Abstract
- Purpose: To correlate the treatment planning parameters with the clinical outcomes in patients treated with accelerated partial breast intensity-modulated radiotherapy.<br />Methods and Materials: A total of 105 patients with Stage I breast cancer were treated between February 2004 and March 2007 in a Phase II prospective trial and had detailed information available on the planning target volume (PTV), ipsilateral breast volume (IBV), PTV/IBV ratio, lung volume, chest wall volume, surgery to radiotherapy interval, follow-up interval, breast pain, and cosmesis. The first 7 of these patients were treated to 34 Gy, and the remaining 98 were treated to 38.5 Gy. All patients were treated twice daily for 5 consecutive days. Univariate and multivariate analyses were performed.<br />Results: The median follow-up was 13 months. No recurrences or deaths were observed. Of the 105 patients, 30 reported mild or moderate breast pain in their most recently recorded follow-up visit. The irradiated lung volume (p < 0.05) and chest wall volume receiving >35 Gy (p < 0.01) were associated with pain. The PTV, but not the PTV/IBV ratio, also correlated with pain (p < 0.01 and p = 0.42, respectively). A total of 72 patients reported excellent, 32 reported good, and 1 reported poor cosmesis. Physician-rated cosmesis reported 90 excellent and 15 good. None of the tested variables correlated with the cosmetic outcomes.<br />Conclusion: Radiotherapy to the chest wall (chest wall volume receiving >35 Gy) and to lung correlated with reports of mild pain after accelerated partial breast intensity-modulated radiotherapy. Also, the PTV, but not the PTV/IBV ratio, was predictive of post-treatment reports of pain.
- Subjects :
- Adult
Aged
Aged, 80 and over
Analysis of Variance
Breast Diseases etiology
Breast Neoplasms pathology
Breast Neoplasms surgery
Esthetics
Female
Follow-Up Studies
Humans
Lung radiation effects
Middle Aged
Pain etiology
Prospective Studies
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Intensity-Modulated adverse effects
Thoracic Wall radiation effects
Treatment Outcome
Tumor Burden
Breast Neoplasms radiotherapy
Radiotherapy, Intensity-Modulated methods
Subjects
Details
- Language :
- English
- ISSN :
- 1879-355X
- Volume :
- 74
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of radiation oncology, biology, physics
- Publication Type :
- Academic Journal
- Accession number :
- 18786783
- Full Text :
- https://doi.org/10.1016/j.ijrobp.2008.06.1917