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[Rituximab treatment for adults with steroid-resistant idiopathic thrombocytopenic purpura].
- Source :
-
Zhonghua nei ke za zhi [Zhonghua Nei Ke Za Zhi] 2008 Mar; Vol. 47 (3), pp. 225-7. - Publication Year :
- 2008
-
Abstract
- Objective: To investigate the efficacy and safety as well as the effects of rituximab on B-lymphocytes and anti-platelet glycoprotein-specific antibodies, in patients with steroid-resistant idiopathic thrombocytopenic purpura (ITP).<br />Methods: Twelve steroid-resistant ITP patients, 16 to 54 years old, received intravenous rituximab at the dose of 375 mg/m2 once--weekly for 4 weeks. Lab studies included CBC, serum concentrations of IgG, IgM and IgA. CD3+, CD4+, CD8+, CD19+, CD20+ cell numbers were assayed by flow cytometry and anti-platelet glycoprotein-specific antibodies (GP IIb/IIa, GP Ib/IX) were assayed by monoclonal antibody-specific immobilisation of platelet antigens prior to and following rituximab therapy.<br />Results: A complete response (platelet counts > or = 100 x 10(9)/L) was observed in 4 cases, a partial response (platelet counts between 50 and 100 x 10(9)/L) in 3 cases, a minor response (platelet counts between 30 and 50 x 10(9)/L) in 2 cases, and nonresponse (platelet counts < 30 x 10(9)/L) in 3 cases. Responses were sustained 0.5 to 12 months (median 5 months). After 4 weeks of rituximab therapy, anti-platelet glycoprotein-specific antibodies (GP IIb/IIIa, GP Ib/IX) disappeared except one NR patient and CD19+/ CD20+ cells were almost depleted in all patients (295.0 +/- 86.4) x 10(6)/L vs (4.1 +/- 2.2) x 10(6)/L (P < 0.01). As expected, the T cell counts, and the serum concentrations of IgG, IgM and IgA were not changed after therapy. No severe side effects were observed.<br />Conclusion: Rituximab may be an effective and safe treatment for adults with steroid-resistant ITP.
- Subjects :
- Adolescent
Adult
Antibodies, Monoclonal, Murine-Derived
Antigens, CD20 immunology
Drug Resistance
Female
Follow-Up Studies
Glucocorticoids therapeutic use
Humans
Immunologic Factors therapeutic use
Male
Middle Aged
Platelet Count
Purpura, Thrombocytopenic, Idiopathic blood
Purpura, Thrombocytopenic, Idiopathic immunology
Rituximab
Treatment Outcome
Young Adult
Antibodies, Monoclonal therapeutic use
Purpura, Thrombocytopenic, Idiopathic drug therapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0578-1426
- Volume :
- 47
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhonghua nei ke za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 18785508