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The single-shot GnRH immunocontraceptive vaccine (GonaCon) in white-tailed deer: comparison of several GnRH preparations.
- Source :
-
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2008 Sep; Vol. 60 (3), pp. 214-23. - Publication Year :
- 2008
-
Abstract
- Problem: An effective, single-injection, multi-year, GnRH contraceptive agent is needed to control reproduction in overabundant white-tailed deer populations.<br />Method of Study: Two GnRH conjugates, GonaCon (GnRH-KLH) and GonaCon-B (GnRH-blue protein), were prepared in emulsion form as one-injection and two-injection immunocontraceptive vaccine formulations. In addition, the GnRH-KLH protein conjugate was lyophilized and suspended in AdjuVac adjuvant to produce a fifth vaccine formulation. Each formulation was administered to a group of five captive adult female white-tailed deer. Reproductive performance of treated female deer was monitored for 5 years to determine the comparative efficacy of the various treatments.<br />Results: The longevity of the contraceptive response (2-5 years) was strongly influenced by the design of the conjugate antigen, the adjuvant used, and the delivery form of the vaccine.<br />Conclusion: One-injection and two-injection formulations of GonaCon and GonaCon-B produced multi-year contraception in adult female white-tailed deer. GonaCon-B provided a longer lasting contraceptive effect.
- Subjects :
- Adjuvants, Immunologic
Animals
Antibodies blood
Female
Gonadotropin-Releasing Hormone administration & dosage
Gonadotropin-Releasing Hormone chemical synthesis
Hemocyanins immunology
Progesterone blood
Vaccines, Contraceptive administration & dosage
Contraception, Immunologic
Deer immunology
Deer physiology
Gonadotropin-Releasing Hormone immunology
Vaccines, Contraceptive immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1046-7408
- Volume :
- 60
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of reproductive immunology (New York, N.Y. : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 18782282
- Full Text :
- https://doi.org/10.1111/j.1600-0897.2008.00616.x