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Nucleoside phosphonic acids in thymidine phosphorylase inhibition: structure-activity relationship.
- Source :
-
Nucleic acids symposium series (2004) [Nucleic Acids Symp Ser (Oxf)] 2008 (52), pp. 665-6. - Publication Year :
- 2008
-
Abstract
- A number of structurally diverse nucleoside phosphonic acids have been tested against human recombinant thymidine phosphorylase and human platelets supernatant using 2'-deoxy-5-nitrouridine as the substrate. We have selected several inhibitors working at micromolar level as lead structures for further evaluation.
- Subjects :
- Animals
Blood Platelets enzymology
CHO Cells
Cricetinae
Cricetulus
Enzyme Inhibitors pharmacology
Humans
Structure-Activity Relationship
Thymidine Phosphorylase chemistry
Enzyme Inhibitors chemistry
Nucleosides chemistry
Nucleosides pharmacology
Organophosphonates chemistry
Thymidine Phosphorylase antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1746-8272
- Issue :
- 52
- Database :
- MEDLINE
- Journal :
- Nucleic acids symposium series (2004)
- Publication Type :
- Academic Journal
- Accession number :
- 18776555
- Full Text :
- https://doi.org/10.1093/nass/nrn336