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Synthesis and conformational analysis of novel 2',3'-didehydo-2',3'-dideoxy-4'-selenonucleosides.
- Source :
-
Nucleic acids symposium series (2004) [Nucleic Acids Symp Ser (Oxf)] 2008 (52), pp. 555-6. - Publication Year :
- 2008
-
Abstract
- The structure of 2',3'-didehydro-2',3'-dideoxynucleosides (d4Ns) was applied to design the novel bioisosteric 4'-seleno-d4Ns as potential inhibitors of human immunodeficiency virus reverse transcriptase (HIV RT). Conversion of 2',3'-dihydroxyl groups of 4'-selenoribofuranosyl pyrimidines into the olefin was accomplished by treatment of cyclic 2',3'-thiocarbonate with 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine.
- Subjects :
- Anti-HIV Agents chemistry
Anti-HIV Agents pharmacology
Dideoxynucleosides chemistry
Dideoxynucleosides pharmacology
Nucleic Acid Conformation
Organoselenium Compounds chemistry
Organoselenium Compounds pharmacology
Reverse Transcriptase Inhibitors chemistry
Reverse Transcriptase Inhibitors pharmacology
Anti-HIV Agents chemical synthesis
Dideoxynucleosides chemical synthesis
Organoselenium Compounds chemical synthesis
Reverse Transcriptase Inhibitors chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1746-8272
- Issue :
- 52
- Database :
- MEDLINE
- Journal :
- Nucleic acids symposium series (2004)
- Publication Type :
- Academic Journal
- Accession number :
- 18776500
- Full Text :
- https://doi.org/10.1093/nass/nrn281