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Total glutathione and glutathione reductase in bovine erythrocytes and liver biopsy.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2008 Aug; Vol. 70 (8), pp. 861-4. - Publication Year :
- 2008
-
Abstract
- The goal of the present study was to measure the total glutathione level and glutathione reductase activity in bovine erythrocytes and liver biopsy. Five cows were injected intraperitoneally with DL-ethionine (12.5 mg/kg B.W.), and two control cows were injected with normal saline (0.9% NaCl). Ultrasonography guided liver biopsy, and blood samples were collected at 0, 4, 7 and 10 days after injection. The hepatic total glutathione level was significantly increased on Days 7 (p<0.05) and 10 (p<0.01), and hepatic glutathione reductase activity was significantly increased on Days 4 (p<0.05), 7 (p<0.01) and 10 (p<0.01). There were insignificant changes in the erythrocytic total glutathione level. The present study demonstrated that liver biopsy is a valuable tool for detecting oxidative stress and for diagnosing hepatic dysfunction in cattle from the viewpoint of the status of glutathione and glutathione reductase.
- Subjects :
- Animals
Biopsy
Cattle
Erythrocytes drug effects
Erythrocytes enzymology
Ethionine pharmacology
Glutathione blood
Glutathione Reductase blood
Glutathione Reductase drug effects
Liver drug effects
Liver enzymology
Liver Glycogen metabolism
Oxidative Stress drug effects
Erythrocytes metabolism
Glutathione metabolism
Glutathione Reductase metabolism
Liver metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0916-7250
- Volume :
- 70
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 18772567
- Full Text :
- https://doi.org/10.1292/jvms.70.861