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Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT.
- Source :
-
Journal of surgical oncology [J Surg Oncol] 2008 Nov 01; Vol. 98 (6), pp. 438-43. - Publication Year :
- 2008
-
Abstract
- Background: The purpose of the current study was to evaluate the accuracy of (18)F-FDG PET/CT in staging hilar cholangiocarcinoma.<br />Materials and Methods: From June 2004 to December 2007, patients evaluated for surgical treatment of hilar cholangiocarcinoma were entered into a prospective database. Dual modality (18)F-FDG PET/CT was performed before surgery. The report was reviewed with comparison to the operative and pathological results in each case for tumour-node-metastasis staging.<br />Results: Seventeen patients (6 women, 11 men) of a median age of 62 years were included in the study. Radical tumour resection was performed on seven patients. Ten patients underwent surgical exploration. The sensitivity of PET/CT in detecting primary tumour was found to be 58.8% (25% in T2 tumour, 70% in T3 tumour, 66.7% in T4 tumour). The sensitivity/specificity of PET/CT in detecting lymph node metastasis and distant metastasis were 41.7%/80% and 55.6%/87.5%, respectively. Positive (18)F-FDG uptake in the bile duct was found to be associated with surgical non-resectability (P = 0.05).<br />Conclusion: Dual-modality PET/CT imaging was found to have a high specificity in detection of lymph node and distant metastasis in hilar cholangiocarcinoma, with a limited value in correct judgement of surgical resectability for tumours in stadium UICC I-III.<br /> ((c) 2008 Wiley-Liss, Inc.)
- Subjects :
- Bile Duct Neoplasms surgery
Bile Ducts, Intrahepatic pathology
Bile Ducts, Intrahepatic surgery
Cholangiocarcinoma surgery
Female
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Neoplasm Metastasis diagnosis
Neoplasm Staging
Prospective Studies
Radiopharmaceuticals
Sensitivity and Specificity
Bile Duct Neoplasms pathology
Cholangiocarcinoma pathology
Positron-Emission Tomography
Preoperative Care
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 1096-9098
- Volume :
- 98
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 18767120
- Full Text :
- https://doi.org/10.1002/jso.21136