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Mania: sympathoadrenal function and clinical state.
- Source :
-
Psychiatry research [Psychiatry Res] 1991 May; Vol. 37 (2), pp. 195-205. - Publication Year :
- 1991
-
Abstract
- We investigated sympathoadrenal and sympathetic nervous system activity, catecholamine disposition, and clinical state in 19 hospitalized manic patients. Severity of the core manic syndrome, anxiety, and hostility correlated with 24-hour urinary excretion of epinephrine relative to its metabolites, but only weakly with norepinephrine. Agitation, however, correlated most strongly and significantly with norepinephrine. Eight of the patients had mixed states: concurrent manic and depressive syndromes. There were no differences between mixed and pure manic patients with respect to catecholamine or metabolite excretion or precursor/product ratios, but mixed manic patients tended to have higher excretion of norepinephrine and had increased variance with respect to catecholamine measures. These data suggest that the function of the adrenal medulla, whether directly or indirectly, is important in the symptoms of both mixed and pure mania.
- Subjects :
- Adult
Anxiety physiopathology
Behavior physiology
Bipolar Disorder physiopathology
Bipolar Disorder psychology
Epinephrine urine
Female
Hostility
Humans
Male
Methoxyhydroxyphenylglycol urine
Middle Aged
Norepinephrine urine
Psychiatric Status Rating Scales
Vanilmandelic Acid urine
Adrenal Medulla metabolism
Bipolar Disorder metabolism
Catecholamines metabolism
Sympathetic Nervous System metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 37
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 1876629
- Full Text :
- https://doi.org/10.1016/0165-1781(91)90075-z