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Computational modeling of volumetric soft tissue growth: application to the cardiac left ventricle.
- Source :
-
Biomechanics and modeling in mechanobiology [Biomech Model Mechanobiol] 2009 Aug; Vol. 8 (4), pp. 301-9. Date of Electronic Publication: 2008 Aug 30. - Publication Year :
- 2009
-
Abstract
- As an initial step to investigate stimulus-response relations in growth and remodeling (G&R) of cardiac tissue, this study aims to develop a method to simulate 3D-inhomogeneous volumetric growth. Growth is regarded as a deformation that is decomposed into a plastic component which describes unconstrained growth and an elastic component to satisfy continuity of the tissue after growth. In current growth models, a single reference configuration is used that remains fixed throughout the entire growth process. However, considering continuous turnover to occur together with growth, such a fixed reference is unlikely to exist in reality. Therefore, we investigated the effect of tissue turnover on growth by incrementally updating the reference configuration. With both a fixed reference and an updated reference, strain-induced cardiac growth in magnitude of 30% could be simulated. However, with an updated reference, the amplitude of the stimulus for growth decreased over time, whereas with a fixed reference this amplitude increased. We conclude that, when modeling volumetric growth, the choice of the reference configuration is of great importance for the computed growth.
Details
- Language :
- English
- ISSN :
- 1617-7940
- Volume :
- 8
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biomechanics and modeling in mechanobiology
- Publication Type :
- Academic Journal
- Accession number :
- 18758835
- Full Text :
- https://doi.org/10.1007/s10237-008-0136-z