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Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer.

Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer.

Authors :
Blackmore KM
Lesosky M
Barnett H
Raboud JM
Vieth R
Knight JA
Source :
American journal of epidemiology [Am J Epidemiol] 2008 Oct 15; Vol. 168 (8), pp. 915-24. Date of Electronic Publication: 2008 Aug 27.
Publication Year :
2008

Abstract

Evidence has emerged for a role of vitamin D in the development of breast cancer, and there is some suggestion that its antiproliferative effect is greater in hormone-receptor-positive cells. Few epidemiologic studies have considered the association between vitamin D and hormone-receptor-defined breast cancer, and the results are conflicting. Considering 759 cases and 1,135 controls from a case-control study (Ontario, Canada, 2003-2005), the authors examined the association between vitamin D intake at specific ages and combined estrogen-receptor- (ER) and progesterone-receptor- (PR) defined breast cancer. While increased intake of vitamin D (from the sun and diet) was most consistently associated with a significantly reduced risk of ER+/PR+ tumors (e.g., odds ratio = 0.76, 95% confidence interval: 0.59, 0.97 for use of cod liver oil during adolescence), comparable nonsignificant associations were found for receptor-negative (ER-/PR-) (odds ratio = 0.74, 95% confidence interval: 0.53, 1.04) and mixed (ER+/PR-) (odds ratio = 0.79, 95% confidence interval: 0.51, 1.22) tumors. This study suggests that vitamin D is associated with a reduced risk of breast cancer regardless of ER/PR status of the tumor. Future studies with a larger number of receptor-negative and mixed tumors are required.

Details

Language :
English
ISSN :
1476-6256
Volume :
168
Issue :
8
Database :
MEDLINE
Journal :
American journal of epidemiology
Publication Type :
Academic Journal
Accession number :
18756015
Full Text :
https://doi.org/10.1093/aje/kwn198