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High risk of vitamin D deficiency in children with sickle cell disease.
- Source :
-
Journal of the American Dietetic Association [J Am Diet Assoc] 2008 Sep; Vol. 108 (9), pp. 1512-6. - Publication Year :
- 2008
-
Abstract
- Vitamin D is a particularly concerning nutrient for children with homozygous SS sickle cell disease (SCD-SS) due to their increased skin melanin concentrations, reduced levels of physical activity, and poor vitamin D intake. The goal of this study was to compare the vitamin D status of children with SCD-SS to healthy African-American children living in the same geographic area. Growth, dietary intake, serum 25-hydroxyvitamin D [25(OH)D], and intact parathyroid hormone (iPTH) concentrations were measured in 61 African-American subjects with SCD-SS and 89 healthy African-American control subjects age 5 to 18 years from the Philadelphia, PA, region (latitude 39.95 degrees N). Median serum 25(OH)D concentrations were 15 ng/mL (95% confidence interval [CI]: 13, 17) in subjects with SCD-SS and 21 ng/mL (95% CI: 18, 22) in healthy control subjects (P<0.0002). Vitamin D deficiency [25(OH)D<11 mg/mL] was found in 33% of subjects with SCD-SS and 9% of healthy control subjects (P<0.001); 25% of subjects with SCD-SS and 17% of healthy control subjects had elevated iPTH [(>59 rhog/mL), P<0.05]. Ninety-three percent of subjects with SCD-SS and 90% of healthy subjects had vitamin D insufficiency [25(OH)D<30 mg/mL]. The risk of vitamin D deficiency among subjects with SCD-SS was 5.3 (95% CI: 2.5, 8.2) times greater than control subjects, adjusted for season and age. Poor vitamin D status was prevalent in children with SCD-SS and healthy African-American children living in the same geographic area. However, children with SCD-SS were at greater risk for vitamin D deficiency than healthy African-American children.
- Subjects :
- Adolescent
Black or African American
Case-Control Studies
Child
Child, Preschool
Female
Humans
Male
Melanins metabolism
Parathyroid Hormone blood
Risk Factors
Seasons
Sunlight
Vitamin D blood
Vitamin D Deficiency blood
Vitamin D Deficiency epidemiology
Anemia, Sickle Cell blood
Anemia, Sickle Cell complications
Nutritional Status
Vitamin D analogs & derivatives
Vitamin D Deficiency etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-8223
- Volume :
- 108
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of the American Dietetic Association
- Publication Type :
- Academic Journal
- Accession number :
- 18755325
- Full Text :
- https://doi.org/10.1016/j.jada.2008.06.433