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Protective effects of curcumin against gamma radiation-induced ileal mucosal damage.
- Source :
-
Archives of toxicology [Arch Toxicol] 2009 Jun; Vol. 83 (6), pp. 609-17. Date of Electronic Publication: 2008 Aug 27. - Publication Year :
- 2009
-
Abstract
- The major objective of this study was to test curcumin as a potential radioprotectant for the ileum goblet cells of the rat. Wistar albino rats were used in the study. Group A was the control group and group B was the single dose radiation group. Group C was the two dose radiation group (4 days interval). The rats in groups D and E were given a daily dose of 100 mg/kg of curcumin for 14 and 18 days, respectively. During the curcumin administration period, the rats in group D were exposed to abdominal area gamma (gamma)-ray dose of 5 Gy on the 10th day and group E was exposed to same dose radiation on the 10th and 14th day. Irradiation and treatment groups were decapitated on the 4th day after exposure to single or two-dose irradiation and ileum tissues were removed for light and electron microscopic investigation. Single or two dose 5 Gy gamma-irradiation caused a marked intestinal mucosal injury in rats on the 4th day. Radiation produced increases in the number of goblet cells. Curcumin appears to have protective effects against radiation-induced damage, suggesting that clinical transfer is feasible.
- Subjects :
- Animals
Antioxidants pharmacology
Goblet Cells drug effects
Goblet Cells radiation effects
Ileum cytology
Ileum drug effects
Ileum radiation effects
Intestinal Mucosa drug effects
Intestinal Mucosa radiation effects
Male
Radiation Injuries etiology
Rats
Rats, Wistar
Time Factors
Curcumin pharmacology
Gamma Rays adverse effects
Radiation Injuries prevention & control
Radiation-Protective Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0738
- Volume :
- 83
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archives of toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 18754102
- Full Text :
- https://doi.org/10.1007/s00204-008-0352-4