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Effect of cyclosporin A and tacrolimus on sister chromatid exchange frequency in renal transplant patients.
- Source :
-
Genetic testing [Genet Test] 2008 Sep; Vol. 12 (3), pp. 427-30. - Publication Year :
- 2008
-
Abstract
- Long-term use of Cyclosporin A (CsA) and Tacrolimus is known to yield serious untoward side effects including nephrotoxicity, neurotoxicity, and malignant tumor formation. Sister chromatid exchange (SCE) is used to assess the genotoxic potential of various agents. A total of 37 postrenal transplant patients receiving either CsA (n = 20) or Tacrolimus (n = 17) were included in this study. The genotoxic effects of CsA and Tacrolimus were assessed by determination of SCE frequency. In patients receiving CsA, SCE frequency was increased significantly compared to that in the control group (p = 0.001), whereas Tacrolimus did not yield such a significant change (p = 0.801). SCE frequency was not correlated with drug dosage (p > 0.05). Our results indicate that the use of CsA, but not Tacrolimus 506, is associated with an increased genotoxic effect in postrenal transplant patients.
- Subjects :
- Adolescent
Adult
Case-Control Studies
Cyclosporine administration & dosage
Cyclosporine therapeutic use
Dose-Response Relationship, Drug
Female
Graft Rejection immunology
Graft Rejection prevention & control
Humans
Immunosuppressive Agents administration & dosage
Immunosuppressive Agents therapeutic use
Male
Middle Aged
Tacrolimus administration & dosage
Tacrolimus therapeutic use
Young Adult
Cyclosporine adverse effects
Immunosuppressive Agents adverse effects
Kidney Transplantation immunology
Kidney Transplantation pathology
Sister Chromatid Exchange drug effects
Tacrolimus adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1090-6576
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Genetic testing
- Publication Type :
- Academic Journal
- Accession number :
- 18752452
- Full Text :
- https://doi.org/10.1089/gte.2008.0006