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Host immune response in B-cell lymphomas: friend or foe?
- Source :
-
Archivum immunologiae et therapiae experimentalis [Arch Immunol Ther Exp (Warsz)] 2008 Jul-Aug; Vol. 56 (4), pp. 245-55. Date of Electronic Publication: 2008 Jul 29. - Publication Year :
- 2008
-
Abstract
- The interaction of B-cell malignancies with the host immune system is a dynamic and bilateral process. Certain lymphomas more commonly arise within a background of autoimmunity or chronic infection. Initiation of these tumors is commonly reliant on antigenic stimulation and/or T-cell help. Apart from its tumor-fueling role, the host immune response plays a critical role in cancer immunosurveillance and immunoediting. The concept of immunoediting holds that the immune system sculpts the tumor's immunogenicity in a dynamic process that involves three essential phases: elimination, equilibrium, and escape. Data obtained by studying gene-targeted animals and human lymphomas that support the critical role of the immune response in the initiation, progression, and immunoediting of lymphoid malignancies are summarized here. A thorough understanding of this interaction will lead to the identification of more rational treatment targets and improved immunotherapies in B-cell lymphomas.
- Subjects :
- Animals
B-Lymphocytes metabolism
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes metabolism
Cytokines immunology
Cytokines metabolism
Histocompatibility Antigens immunology
Histocompatibility Antigens metabolism
Humans
Inflammation metabolism
Killer Cells, Natural immunology
Killer Cells, Natural metabolism
Lymphoma, B-Cell genetics
Lymphoma, B-Cell metabolism
Lymphoma, B-Cell pathology
B-Lymphocytes immunology
Immunologic Surveillance
Inflammation immunology
Lymphoma, B-Cell immunology
Tumor Escape
Subjects
Details
- Language :
- English
- ISSN :
- 0004-069X
- Volume :
- 56
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Archivum immunologiae et therapiae experimentalis
- Publication Type :
- Academic Journal
- Accession number :
- 18726146
- Full Text :
- https://doi.org/10.1007/s00005-008-0028-z