Back to Search
Start Over
Synthesis of new 1-phenyl-3-{4-[(2E)-3-phenylprop-2-enoyl]phenyl}-thiourea and urea derivatives with anti-nociceptive activity.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2008 Sep 15; Vol. 16 (18), pp. 8526-34. Date of Electronic Publication: 2008 Aug 08. - Publication Year :
- 2008
-
Abstract
- Chalcones or 1,3-diaryl-2-propen-1-ones are known to be useful for treating pain, inflammation, and certain diseases although their uses have not been scientifically verified. Due to the limitations of opioid and NSAID therapy, there is a continuing search for new analgesics. A series of novel new 1-phenyl-3-{4-[(2E)-3-phenylprop-2-enoyl]phenyl}-thiourea and urea derivatives were synthesized and evaluated against writhing test in mice, following the aromatic substitution pattern proposed by Topliss. The results of the preliminary bioassays indicate that compound 3 presents promising anti-nociceptive activity in acetic acid-, formalin-, and glutamate-induced pain in mice, compared with some well-known non-steroidal anti-inflammatory and analgesic drugs.
- Subjects :
- Analgesics chemical synthesis
Animals
Anti-Inflammatory Agents, Non-Steroidal chemical synthesis
Biological Assay
Mice
Pain Measurement
Structure-Activity Relationship
Thiourea analogs & derivatives
Thiourea chemical synthesis
Urea analogs & derivatives
Urea chemical synthesis
Analgesics pharmacology
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Thiourea pharmacology
Urea pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 16
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18722128
- Full Text :
- https://doi.org/10.1016/j.bmc.2008.08.019